2056 Results for "

Trichodesma incanum (Bunge) A.DC.

" in MedChemExpress (MCE) Product Catalog:
Products (2056)

2056 Results for "Trichodesma incanum (Bunge) A.DC." in MCE Product Catalog:

97
VcMMAE
VcMMAE
0 Images
97 Publications Verification
Cat. No.: HY-15575
CAS No.: 646502-53-6
Purity:  99.94%
Synonyms: MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE; Vedotin
Target:  

Drug-Linker Conjugates for ADC Microtubule/Tubulin

Research Areas:  

Cancer

VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
59
Monomethyl auristatin E
Monomethyl auristatin E
0 Images
59 Cited Publications
Cat. No.: HY-15162
CAS No.: 474645-27-7
Purity:  99.97%
Synonyms: MMAE; SGD-1010
Target:  

Microtubule/Tubulin ADC Payloads Apoptosis

Research Areas:  

Cancer

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
47
Cryptotanshinone
Cryptotanshinone
0 Images
47 Cited Publications
Cat. No.: HY-N0174
CAS No.: 35825-57-1
Synonyms: Cryptotanshinon; Tanshinone c
Category:  

Quinones Labiatae Samanea saman (Jacq.) Merr. Plants Disease Research Fields Naphthalene Quinones Cancer

Target:  

STAT Autophagy

Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
36
Tanshinone IIA
Tanshinone IIA
0 Images
36 Cited Publications
Cat. No.: HY-N0135
CAS No.: 568-72-9
Synonyms: Dan Shen ketone
Category:  

Quinones Labiatae Terpenoids Samanea saman (Jacq.) Merr. Diterpenoids Plants Disease Research Fields Naphthalene Quinones Cancer

Target:  

VEGFR

Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
31
Deruxtecan
Deruxtecan
0 Images
31 Cited Publications
Cat. No.: HY-13631E
CAS No.: 1599440-13-7
Purity:  99.94%
Synonyms: MC-GGFG-DXD
Target:  

Drug-Linker Conjugates for ADC

Research Areas:  

Cancer

Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813) .
28
Mertansine
Mertansine
0 Images
28 Cited Publications
Cat. No.: HY-19792
CAS No.: 139504-50-0
Synonyms: DM1; Maytansinoid DM1
Target:  

Microtubule/Tubulin ADC Payloads

Research Areas:  

Cancer

Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC) .
14
DXd
DXd
0 Images
14 Cited Publications
Cat. No.: HY-13631D
CAS No.: 1599440-33-1
Purity:  99.30%
Synonyms: Exatecan derivative for ADC
Target:  

Topoisomerase ADC Payloads

Research Areas:  

Cancer

DXd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
14
Dihydrotanshinone I
Dihydrotanshinone I
0 Images
14 Cited Publications
Cat. No.: HY-N0360
CAS No.: 87205-99-0
Category:  

Cardiovascular Disease Quinones Labiatae Samanea saman (Jacq.) Merr. Plants Phenanthrenequinones Disease Research Fields

Target:  

SARS-CoV

Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.
12
SMCC-DM1
SMCC-DM1
0 Images
12 Cited Publications
Cat. No.: HY-101070
CAS No.: 1228105-51-8
Purity:  99.23%
Synonyms: DM1-SMCC
Target:  

Drug-Linker Conjugates for ADC

Research Areas:  

Cancer

SMCC-DM1 (DM1-SMCC) is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody agent conjugate (ADC) .
11
Sacituzumab govitecan
Sacituzumab govitecan
0 Images
11 Cited Publications
Cat. No.: HY-132254
CAS No.: 1491917-83-9
Purity:  99.13%
Synonyms: IMMU-132
Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. The antibody portion is Sacituzumab (HY-P99045), and the drug-linker conjugate for ADC is CL2A-SN-38 (HY-128946). Sacituzumab govitecan shows anticancer activity .
11
Sacituzumab govitecan (solution)
Sacituzumab govitecan (solution)
0 Images
11 Cited Publications
Cat. No.: HY-132254A
CAS No.: 1491917-83-9
Purity:  96.61%
Synonyms: IMMU-132 (solution)
Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. The antibody portion is Sacituzumab (HY-P99045), and the drug-linker conjugate for ADC is CL2A-SN-38 (HY-128946). Sacituzumab govitecan shows anticancer activity .
9
Trastuzumab deruxtecan (solution)
Trastuzumab deruxtecan (solution)
0 Images
9 Cited Publications
Cat. No.: HY-138298
CAS No.: 1826843-81-5
Purity:  98.90%
Synonyms: T-DXd (solution); DS-8201 (solution); DS-8201a (solution)
Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer .
9
Trastuzumab deruxtecan
Trastuzumab deruxtecan
0 Images
9 Cited Publications
Cat. No.: HY-138298A
CAS No.: 1826843-81-5
Purity:  99.58%
Synonyms: T-DXd; DS-8201; DS-8201a
Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer .
8
MMAF hydrochloride
MMAF hydrochloride
0 Images
8 Cited Publications
Cat. No.: HY-15579A
CAS No.: 1415246-68-2
Purity:  99.93%
Synonyms: Monomethylauristatin F hydrochloride
Target:  

Microtubule/Tubulin ADC Payloads

Research Areas:  

Cancer

MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .
8
MMAF
MMAF
0 Images
8 Cited Publications
Cat. No.: HY-15579
CAS No.: 745017-94-1
Purity:  99.92%
Synonyms: Monomethylauristatin F
Target:  

Microtubule/Tubulin ADC Payloads

Research Areas:  

Cancer

MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .
8
MMAF sodium
MMAF sodium
0 Images
8 Cited Publications
Cat. No.: HY-15579B
CAS No.: 1799706-65-2
Purity:  99.59%
Synonyms: Monomethylauristatin F sodium
Target:  

Microtubule/Tubulin ADC Payloads

Research Areas:  

Cancer

MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .
8
McMMAF
McMMAF
0 Images
8 Cited Publications
Cat. No.: HY-15578
CAS No.: 863971-19-1
Purity:  99.96%
Synonyms: Maleimidocaproyl monomethylauristatin F
Target:  

Drug-Linker Conjugates for ADC Apoptosis

Research Areas:  

Cancer

McMMAF (Maleimidocaproyl monomethylauristatin F) is an active molecule linker for ADC, made by coupling the powerful microtubule inhibitor Monomethyl auristatin F (MMAF) (HY-15579) with the protecting group maleimidocaproyl. McMMAF can be conjugated with anti-BCMA antibodies to form J6M0-mcMMAF, promoting apoptosis and inhibiting tumor growth .
8
Sacituzumab
Sacituzumab
0 Images
8 Cited Publications
Cat. No.: HY-P99045
CAS No.: 1796566-95-4
Synonyms: HRS7; hRS7

Target:  

ADC Antibodies TROP2

Research Areas:  

Cancer

Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer .
7
Trastuzumab emtansine (solution)
Trastuzumab emtansine (solution)
0 Images
7 Cited Publications
Cat. No.: HY-P9921A
CAS No.: 1018448-65-1
Synonyms: Ado-Trastuzumab emtansine (solution); PRO132365 (solution); T-DM 1 (solution)
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine), and the drug-linker conjugate for ADC is SMCC-DM1 (HY-101070). Trastuzumab emtansine can be used for the research of advanced breast cancer .
7
Tesirine
Tesirine
0 Images
7 Cited Publications
Cat. No.: HY-128952
CAS No.: 1595275-62-9
Purity:  98.10%
Synonyms: SG3249
Target:  

Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker

Research Areas:  

Cancer

Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
Assay Types